Table 1.
Firing and EEG-properties in medial entorhinal cortex and hippocampus
| iWT | iCre-KO | ||
|---|---|---|---|
|
|
|||
| border cells | |||
| n | 86 | 71 | |
| border score | 0.62 ± 0.092 | 0.61 ± 0.080 | WRS Z = −0.20, p = 0.84 |
| mean firing rate | 1.13 ± 2.50 Hz | 1.01 ± 1.73 Hz | WRS Z = 0.34, p = 0.73 |
| peak firing rate | 3.69 ± 5.09 Hz | 3.53 ± 5.00 Hz | WRS Z = 0.22, p = 0.83 |
| spatial stability | 0.31 ± 0.22 | 0.27 ± 0.22 | WRS Z = 0.87, p = 0.38 |
| border width | 14.43 ± 6.53 cm | 14.23 ± 5.22 cm | WRS Z =−0.30, p = 0.76 |
| spatially stable cells | |||
| n | 32 | 38 | |
| mean firing rate | 1.15 ± 1.11 Hz | 1.99 ± 2.21 Hz | WRS Z = −1.20, p = 0.23 |
| peak firing rate | 5.00 ± 4.37 Hz | 6.15 ± 1.00 Hz | WRS Z = −1.73, p = 0.084 |
| spatial stability | 0.37 ± 0.15 | 0.37 ± 0.17 | WRS Z = 0.19, p = 0.85 |
| mean field size | 2473.45 ± 2233.2 cm2 | 2692.29 ± 2768.8 cm2 | WRS Z = 0.12, p = 0.90 |
| % box covered by fields | 43.24 ± 30.72 % | 45.58 ± 31.62 % | WRS Z = −0.15, p = 0.88 |
| interneurons | |||
| n | 15 | 22 | |
| mean firing rate | 23.33 ± 26.46 Hz | 23.37 ± 16.11 Hz | WRS Z = −1.38, p = 0.17 |
| peak firing rate | 37.22 ± 36.48 Hz | 38.85 ± 19.89 Hz | WRS Z = −1.50, p = 0.13 |
| bursting | 19.33 ± 14.55 % | 21.50 ± 16.20 % | WRS Z = 0, p > 0.99 |
| theta-modulated interneurons, n | 13 | 16 | |
| interspike interval | 96.92 ± 14.65 s | 98.75 ± 16.07 s | WRS Z = −0.36, p = 0.72 |
| head direction cells | |||
| layer II/III, n | 176 | 185 | |
| head direction score | 0.36 ± 0.21 | 0.37 ± 0.20 | WRS Z = −1.32, p = 0.19 |
| mean firing rate | 1.24 ± 7.62 Hz | 0.72 ± 1.22 Hz | WRS Z = 0.15, p = 0.88 |
| peak firing rate | 3.66 ± 11.37 Hz | 2.98 ± 3.81 Hz | WRS Z = −0.50, p = 0.62 |
| directional stability | 0.46 ± 0.29 | 0.46 ± 0.29 | WRS Z = −0.18, p = 0.86 |
| tuning width | 124.77 ± 72.86° | 128.43 ± 81.51° | WRS Z = 0.0071, p = 0.99 |
| layer V, n | 49 | 55 | |
| head direction score | 0.41 ± 0.26 | 0.40 ± 0.20 | WRS Z = −0.64, p = 0.52 |
| mean firing rate | 0.54 ± 0.75 Hz | 0.84 ± 1.70 Hz | WRS Z = −0.036, p = 0.97 |
| peak firing rate | 2.08 ± 2.34 Hz | 3.00 ± 4.49 Hz | WRS Z = −0.35, p = 0.73 |
| directional stability | 0.55 ± 0.27 | 0.52 ± 0.20 | WRS Z = 0.83, p = 0.41 |
| tuning width | 126.61 ± 80.08° | 126.55 ± 78.98° | WRS Z = −0.42, p = 0.67 |
| speed cells | |||
| n | 69 | 89 | |
| speed score | 0.11 ± 0.056 | 0.11 ± 0.055 | WRS Z = −0.074, p = 0.94 |
| mean firing rate | 3.39 ± 12.41 Hz | 3.088 ± 9.72 Hz | WRS Z = 0.11, p = 0.92 |
| peak firing rate | 6.89 ± 18.39 Hz | 6.40 ± 13.12 Hz | WRS Z = −0.50, p = 0.61 |
| slope (hz/cm/s) | 0.018 ± 0.025 | 0.024 ± 0.047 | WRS Z = −0.070, p = 0.94 |
| MEC EEG (layer II) | |||
| n | 12 | 16 | |
| theta power | 0.75 ± 0.34 | 0.80 ± 0.47 | WRS Z = 0, p > 0.99 |
| theta frequency | 8.82 ± 0.22 Hz | 8.79 ± 0.25 Hz | WRS Z = 0.35, p = 0.73 |
| theta slope (Hz/cm/s) | 0.011 ± 0.0067 | 0.014 ± 0.0081 | WRS Z = −1.27, p = 0.20 |
| fast gamma power | 0.092 ± 0.024 | 0.092 ± 0.039 | WRS Z = 0.023, p = 0.98 |
| slow gamma power | 0.27 ± 0.068 | 0.23 ± 0.085 | WRS Z = 1.18, p = 0.24 |
| hippocampal EEG | |||
| n | 11 | 8 | *p-value using exact method |
| theta power | 0.89 ± 0.40 | 0.85 ± 0.32 | WRS, p > 0.99 |
| theta frequency | 8.74 ± 0.29 Hz | 8.77 ± 0.12 Hz | WRS, p = 0.86 |
| theta slope (Hz/cm/s) | 0.016 ± 0.01 | 0.015 ± 0.0053 | WRS, p = 0.90 |
| fast gamma power | 0.082 ± 0.049 | 0.087 ± 0.026 | WRS, p = 0.60 |
| slow gamma power | 0.25 ± 0.097 | 0.32 ± 0.066 | WRS, p = 0.091 |
| place cells | |||
| n | 113 | 126 | |
| number of fields | 1.95 ± 1.16 | 1.71 ± 1.09 | WRS Z = 1.66, p = 0.10 |
| peak firing rate | 3.50 ± 2.55 Hz | 4.38 ± 4.32 Hz | WRS Z = −1.30, p = 0.19 |
| mean in-field firing rate | 1.41 ± 1.02 Hz | 1.84 ± 1.98 Hz | WRS Z = −1.09, p = 0.27 |
| bursting | 4.76 ± 6.40 %, | 5.52 ± 4.29 % | WRS Z = −1.00, p = 0.32 |
Mean ± SD. Cells are used as experimental units except for EEG measures, where mice are used. All WRS tests were two tailed.