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. 2018 Jan 2;9(10):8927–8940. doi: 10.18632/oncotarget.23826

Figure 3. Let-7c inhibits colony formation, proliferation, and migration in HNSCC cell lines.

Figure 3

HNSCC cell lines SAS and Ca9-22 were transfected with either pCMV-MIR vector or pCMV-MIR-let-7c vector. Cells were subjected to assays of (A, B) colony formation, (C, D) proliferation, and (E) migration to examine growth of in vitro cancer cell cultures. P-values were calculated using the Student’s t-test. Following re-expression of IGF1R or HMGA2 in SAS-let-7c cells using pCMV6-IGF1R or pCMV6-HMGA2, cells were subjected to assays of (F) proliferation and (G) migration. P-values of F and G were derived from two-way ANOVA and one-way ANOVA followed by Bonferroni correction, respectively. *P < 0.05; **P < 0.01; ***P < 0.001.