Figure 2. Association between chromosomal copy number aberrations and differential expression of genes.

(A) Frequencies of gains (pointing outbound) and losses (pointing inbound) of the given chromosomal region as obtained from integrative analysis of three aCGH datasets. The aberration frequencies are depicted in range from 0-50% and regions with significant frequency of aberrations are highlighted by color (orange – losses, green – gains). Precise chromosomal locations of these paradoxical genes are depicted in the circular plot. (B) Tumor-vs-normal expression fold change of the paradoxical genes, obtained across 10 publicly available datasets. In Figures A and B, symbols of the downregulated genes are labeled red, while the symbols of the upregulated genes are labeled blue. (C) Venn diagram showing overlaps between up-/downregulated genes and genes residing within the regions of chromosomal copy number gain, or loss.