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. 2018 Jan 9;9(10):9021–9029. doi: 10.18632/oncotarget.24078

Figure 2.

Figure 2

(A) Flow cytometry detection of CAR expression on the surface of transduced FnCAR T cells, as assayed by anti-myc staining. (B) VEGFR2-specific FnCAR-T cells but not irrelevant CAR-T cells (gated by the expression of CAR) become activated (CD69+) upon incubation with target PC3(VEGFR2+) cells. (C) PC3(VEGFR2+) target cell killing by VEGFR2-specific FnCAR-T cells (note that only ~30% of effector T cell population is FnCAR-positive, (A)), but not by irrelevant CD20-specific k20-28z CAR-T cells.