Figure 1. Pazopanib pre-treatment significantly increased tumor response to SDRT in JJ012 and MPNST3 sarcoma tumor models.

MPNST3 tumor tissue was transplanted subcutaneously into the right flank of ICR-SCID mice (A) and JJ012 cells were implanted subcutaneously into the right flank of athymic mice (15 × 10⁶cells/mouse) (B). When the tumors reached the volume of ~150 mm³, the mice were administered a single p.o. dose of Pazopanib (100 mg/kg) at 1 h or two p.o. doses at 8 h and 1 h prior to 30 Gy or 15 Gy SDRT. The tumor volumes were measured for the indicated days. Volumes are mean ± SEM. Arrows indicate the day of SDRT. (^*p < 0.05; 30 Gy vs 30 Gy + Paz and 15 Gy vs15 Gy + Paz).