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. 2018 Jan 10;9(10):9425–9441. doi: 10.18632/oncotarget.24114

Figure 7. Silencing GRP94 suppressed the AKT and MAPK-mediated pathways.

Figure 7

(A) The levels of AKT, p-AKT, JNK, p-JNK, p38, ERK and p-ERK were determined. Activation of AKT and ERK was suppressed in GRP94-silenced cells. (B) The levels of COX-2, VEGF, IL-6, c-Jun, c-Fos, and NF-kB were determined by western blotting. (C) Schematic showing how silencing GRP94 may inhibit the AKT and MAPK pathways. The subsequent reduction of COX-2, IL-6, and VEGF may be due to the reduction of NF-kB activation and AP-1 production.