Table 2. Univariate and multivariate survival analysis of associations between marital status and CSS in SEER database patients.

		Univariate analysis		Multivariate analysis
Variable	5-year CCS	Log rank χ2 test	P	HR (95% CI)	P
Sex		0.480	0.488		NI
Male	17.0%
Female	17.2%
Age		271.377	< 0.001
≤60	20.9%			Reference
>60	15.7%			1.388 (1.338–1.441)	< 0.001
Race		39.979	< 0.001
White	16.9%			Reference
Black	15.2%			1.049 (0.995–1.105)	0.77
Other*	19.7%			0.896 (0.856–0.938)	< 0.001
Tumor site		1197.390	< 0.001
Gallbladder	19.6%			Reference
Bile duct	10.5%			0.847 (0.815–0.881)	< 0.001
Ampulla of Vater	34.6%			0.569 (0.538–0.602)	< 0.001
AJCC 6th TNM stage		4995.646	< 0.001
I	41.4%			Reference
II	21.2%			1.553 (1.446–1.668)	< 0.001
III	13.3%			1.652 (1.525–1.789)	< 0.001
IV	2.0%			2.225 (2.007–2.466)	< 0.001
Unknown	8.1%			1.969 (1.816–2.135)	< 0.001
Grade		2945.362	< 0.001
I	41.4%			Reference
II	28.7%			1.275 (1.180–1.377)	< 0.001
III	15.6%			1.761 (1.630–1.902)	< 0.001
IV	17.1%			1.631 (1.372–1.939)	< 0.001
Unknown	7.4%			1.461 (1.353–1.577)	< 0.001
SEER Stage		3717.179	< 0.001
Localized	34.9%			Reference
Regional	21.1%			1.118 (1.047–1.193)	< 0.001
Distant	3.3%			1.212 (1.101–1.334)	< 0.001
Unknown	7.8%			1.000 (0.917–1.091)	< 0.001
Therapy		5505.595	< 0.001
Surgery	33.3%			Reference
No surgery	4.1%			2.448 (2.336–2.566)	< 0.001
Unknown	9.0%			1.962 (1.687–2.283)	< 0.001
Marital Status		284.788	< 0.001
Married	18.7%			Reference
Widowed	13.9%			1.245 (1.196–1.295)	< 0.001
Never married	17.9%			1.142 (1.090–1.197)	< 0.001
Divorced/Separated	14.4%			1.135 (1.077–1.196)	< 0.001

^* Other includes American Indian/Alaska native, Asian/Pacific Islander, and unknown. NI: not included in the multivariate survival analysis.