Table 2. Top canonical pathways related to adipose tissues in the VAT/BAT comparison following a HFD.
| Activated canonical pathways in VAT relative to BAT | -log (p-value) | Ratio | z-score | Differential/total genes |
|---|---|---|---|---|
| Integrin Signaling | 15.300 | 0.479 | 8.342 | 105/219 |
| NRF2-mediated Oxidative Stress Response | 14.300 | 0.487 | 5.571 | 94/193 |
| B Cell Receptor Signaling | 13.700 | 0.486 | 7.117 | 90/185 |
| IL8 Signaling | 12.600 | 0.467 | 8.786 | 92/197 |
| PI3K/AKT Signaling | 12.500 | 0.532 | 3.357 | 66/124 |
| Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes | 12.400 | 0.581 | 7.076 | 54/93 |
| PI3K Signaling in B Lymphocytes | 12.200 | 0.523 | 6.786 | 67/128 |
| mTOR Signaling | 10.900 | 0.447 | 5.422 | 89/199 |
| NGF Signaling | 10.500 | 0.513 | 7.353 | 60/117 |
| PDGF Signaling | 9.930 | 0.544 | 6.143 | 49/90 |
| Inhibited canonical pathways in VAT relative to BAT | -log (p-value) | Ratio | z-score | No of genes |
| PTEN Signaling | 8.600 | 0.479 | −4.160 | 57/119 |
| RhoGDI Signaling | 8.580 | 0.434 | −5.500 | 75/173 |
| PPARα/RXRα Activation | 6.420 | 0.399 | −2.655 | 71/178 |
| PPAR Signaling (PPARα) | 2.950 | 0.376 | −4.226 | 35/93 |
| Role of p14/p19ARF in Tumor Suppression | 2.750 | 0.442 | −3.300 | 19/43 |
–log p value > 1.3 is equivalent to p value < 0.05 and is significant. Ratio is number of differentially expressed/total number of genes in a canonical pathway. Z score ≤ −2 is inhibited and ≥ 2 is activated. Abbreviations: AKT (protein kinase B), ARF (alternative reading frame), IL8 (Interleukin-8), PI3K (phosphoinositide 3-kinase), mTOR (mechanistic target of rapamycin), NGF (nerve growth factor), NRF2 (nuclear factor-erythroid 2-related factor), PPAR (peroxisome proliferator activated receptor), PDGF (platelet-derived growth factor), PTEN (phosphatase and tensin homolog), RhoGDI (Rho GDP-dissociation inhibitor), and RXR (Retinoid X receptor).