Figure 1.

Perforin mutations are present in all domains and subdomains of this pore‐forming protein. (a) Genomic organization of PRF1 with indicated domains and subdomain. (b) List of amino acids, using single letter code, with corresponding mutations. Lower case letters indicate that there is a frameshift or deletion that results in an amino acid termination later in the protein. An “X” indicated a termination at that amino acid (c) 3D rendering (cartoon, mesh, surface) of perforin structure