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Stability of the FKFL linker in human serum. Peptide monomers/polymers (400 μM) were incubated in human serum, and peptide products were extracted and analyzed by MALDI-TOF MS. Spectra at 12 h are shown. (A, C) Peptide monomers (3437 Da) underwent low levels of cleavage at the FKFL linker to release FLAhxBIM, as indicated by the appearance of a 2980 Da peak. (B, D) In contrast, formulation into polymers prevented undesired cleavage of the FKFL linker by serum proteases.
