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. Author manuscript; available in PMC: 2018 May 1.
Published in final edited form as: Mol Pharm. 2017 Mar 30;14(5):1450–1459. doi: 10.1021/acs.molpharmaceut.6b01178

Figure 4.

Figure 4

The diblock copolymers demonstrate pH-responsive membrane destabilizing activity. (A) Dynamic light scattering (DLS) was employed to measure particle diameters in phosphate buffers of varying pH. At pH 7.4 the polymers formed micelles, which disassembled into unimers of smaller diameter at more acidic pH values. (B) A red blood cell lysis assay demonstrated a corresponding increase in membrane destabilizing activity with a decrease in pH. Red blood cells were incubated with polymers (60 μg/mL), and % heme release (abs 541 nm) was quantified relative to a 0.1% Triton X-100 positive control.