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. Author manuscript; available in PMC: 2018 Nov 9.
Published in final edited form as: J Med Chem. 2017 Oct 25;60(21):8906–8922. doi: 10.1021/acs.jmedchem.7b01154

Figure 1.

Figure 1

The interacting trimeric structure of human CD40–CD40L shown from two different perspectives: a side view (left) and a 90°-rotated top view (right). CD40L and CD40 are shown in blue and red hues, respectively using crystal structure of the complex (PDB ID 3QD610, which is lacking one of the CD40 monomers). For size comparison, side chains are shown on one of CD40L monomers and our present small molecule of interest (10) is included as a separate stick structure.