Table 2.

Pooled HBV reactivation rates in inflammatory arthritis patients with resolved hepatitis B

Resolved HBV*	Antiviral prophylaxis (−)
	N	Event	Pooled Rate,% (95%CI)	P value**
Summary	1,032	16	1.6 (0.8–2.6)	0.27
TNF-alpha inhibitors	629	8	1.4 (0.5–2.6)	0.26
Non-TNF biologics	69	3	6.1 (0.0–16.6)	0.08
Non-biologic DMARDs	334	5	1.7 (0.2–4.2)	0.23

^*Resolved HBV: HbsAg (−), HbcAb (+);

^**P value for study heterogeneity within DMARD classes.

In all studies included in this meta-analysis, no patient with resolved HBV was treated with antiviral prophylaxis.

Abbreviations: TNF: tumor necrosis factor; DMARD: Disease Modifying Anti-Rheumatic Drugs.