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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: Psychopharmacology (Berl). 2017 Nov 27;235(3):789–802. doi: 10.1007/s00213-017-4794-3

Figure 2.

Figure 2

Stop Error – Go contrast from Stop Signal Task using whole-brain voxelwise fMRI analysis corrected for multiple comparisons (pcorrected<0.05). A. Significant DRUG × GROUP interaction where individuals with schizophrenia had increased nicotine-induced activation of the right caudate in response to errors compared to placebo. In contrast, there was no significant DRUG effect for control participants; individuals with schizophrenia had significantly greater right caudate activation than controls under the nicotine condition (C). B. Significant DRUG effects in the rostral anterior cingulate (rACC: yellow, D) and the dorsomedial anterior prefrontal cortex (aPFC: red, E) with increased nicotine-induced activation in both regions. Data in C-E represent mean contrast parameter extracted from clusters identified using whole-brain analysis for the Stop Error – Go contrast (averaged over each region).