Table 4.
Resting State Data: Whole-Brain Analysis
| Seed Regiona | Areas of Decreased Connectivityb | Side | Volume (# voxels) | tc | Peak activity: MNI coordinates | ||
|---|---|---|---|---|---|---|---|
| x | y | z | |||||
| Right Caudate | Dorsolateral prefrontal cortex | R | 63 | 5.4 | 32 | 37 | 32 |
| Dorsal anterior cingulate | R | 26 | 5.6 | 11 | 34 | 30 | |
| Dorsolateral prefrontal cortex | L | 24 | 4.3 | −28 | 28 | 38 | |
| Anterior prefrontal cortex (dorsomedial superior frontal gyrus) | Cuneus | R | 24 | 3.8 | 17 | −56 | 5 |
| Rostral anterior cingulate cortex/Medial prefrontal cortex | Cuneus | R | 36 | 4.2 | 23 | −53 | 2 |
a
Clusters with significant DRUG effect or DRUG × GROUP effect from Stop Error – Go contrast were used as seed regions.
b
Areas with significant decreases in connectivity in schizophrenia compared to controls (GROUP effect: pcorrected < 0.05)
c
t-statistic for Control – Schizophrenia group comparison (peak voxel)