Table 4.
Association between row-based radiographic severity and presence of hand pain
| Radiographic Definition | Absence of | Presence of | Crude | Adjusted* |
|---|---|---|---|---|
| Hand Pain (n=2806) | Hand Pain (n=798) | OR (95% CI) | OR (95% CI) | |
| n (%) | n (%) | [c-statistic or AUC] | [c-statistic or AUC] | |
| DIP row (DIP2 to DIP5): Number of KL >=2 | ||||
|
| ||||
| 0 joints | 1519 (56.7) | 313 (39.2) | (ref) | (ref) |
| 1 joint | 493 (17.6) | 131 (16.4) | 1.35 (1.08, 1.70) | 1.44 (1.13, 1.82) |
| 2 joints | 259 (9.2) | 93 (11.7) | 1.83 (1.40, 2.38) | 1.90 (1.43, 2.53) |
| 3 joints | 165 (5.9) | 77 (9.7) | 2.37 (1.76, 3.19) | 2.43 (1.77, 3.35) |
| 4 joints | 297 (10.6) | 184 (23.1) | 3.15 (2.53, 3.93) | 3.19 (2.46, 4.12) |
| [0.561] | [0.786] | |||
|
| ||||
| PIP row (PIP2 to PIP5): Number of KL >=2 | ||||
|
| ||||
| 0 joints | 2140 (76.3) | 466 (58.4) | (ref) | (ref) |
| 1 joint | 283 (10.1) | 97 (12.2) | 1.57 (1.22, 2.02) | 1.60 (1.24, 2.08) |
| 2 joints | 141 (5.0) | 75 (9.4) | 2.44 (1.81, 3.29) | 2.40 (1.76, 3.27) |
| 3 joints | 90 (3.2) | 64 (8.0) | 3.27 (2.33, 4.57) | 3.25 (2.28, 4.62) |
| 4 joints | 151 (5.4) | 96 (12.0) | 2.92 (2.22, 3.84) | 2.71 (2.00, 3.66) |
| [0.577] | [0.767] | |||
|
| ||||
| MCP row (MCP2 to MCP5): Number of KL >=2 | ||||
|
| ||||
| 0 joints | 2577 (91.8) | 692 (86.7) | (ref) | (ref) |
| 1 joint | 172 (6.1) | 68 (8.5) | 1.47 (1.10, 1.97) | 1.52 (1.12, 2.06) |
| 2–4 jointsǂ | 57 (2.1) | 38 (4.8) | 2.48 (1.63, 3.78) | 2.79 (1.80, 4.32) |
| [0.552] | [0.751] | |||
|
| ||||
| DIP row (DIP2 to DIP5): Number of KL >=3 | ||||
|
| ||||
| 0 joints | 2592 (92.4) | 611 (76.6) | (ref) | (ref) |
| 1 joint | 112 (4.0) | 68 (8.5) | 2.58 (1.88, 3.53) | 2.43 (1.75, 3.38) |
| 2 joints | 52 (1.9) | 51 (6.4) | 4.16 (2.80, 6.18) | 3.97 (2.63, 5.99) |
| 3–4 jointsǂ | 49 (1.8) | 68 (8.5) | 5.89 (4.04, 8.59) | 5.67 (3.80, 8.46) |
| [0.638] | [0.834] | |||
|
| ||||
| PIP row (PIP2 to PIP5): Number of KL >=3 | ||||
|
| ||||
| 0 joints | 2743 (97.8) | 715 (89.6) | (ref) | (ref) |
| 1 joint | 47 (1.7) | 49 (6.1) | 4.00 (2.66, 6.02) | 3.73 (2.45, 5.68) |
| 2–4 jointsǂ | 15 (0.5) | 34 (4.3) | 8.70 (4.71, 16.05) | 7.59 (4.04, 14.26) |
| [0.683] | [0.814] | |||
|
| ||||
| MCP row (MCP2 to MCP5): Number of KL >=3 | ||||
|
| ||||
| 0 joints | 2777 (99.0) | 769 (96.4) | (ref) | (ref) |
| 1–4 jointsǂ | 29 (1.0) | 29 (3.6) | 3.61 (2.15, 6.08) | 4.04 (2.35, 6.96) |
| [0.642] | [0.836] | |||
|
| ||||
| DIP row (DIP2 to DIP5): Number of KL >=4 | ||||
|
| ||||
| 0 joints | 2760 (98.4) | 747 (93.6) | (ref) | (ref) |
| 1 joint | 26 (0.9) | 23 (2.9) | 3.27 (1.85, 5.76) | 2.69 (1.51, 4.81) |
| 2–4 jointsǂ | 19 (0.7) | 28 (3.5) | 5.45 (3.02, 9.81) | 4.27 (2.34, 7.80) |
| [0.659] | [0.850] | |||
|
| ||||
| PIP row (PIP2 to PIP5): Number of KL >=4 | ||||
|
| ||||
| 0 joints | 2794 (99.6) | 778 (97.5) | (ref) | (ref) |
| 1–4 jointsǂ | 11 (0.4) | 20 (2.5) | 6.53 (3.12, 13.69) | 5.55 (2.61, 11.82) |
| [0.714] | [0.872] | |||
|
| ||||
| MCP row (MCP2 to MCP5): Number of KL >=4 | ||||
|
| ||||
| 0 joints | 2798 (99.7) | 789 (98.9) | (ref) | (ref) |
| 1–4 jointsǂ | 8 (0.3) | 9 (1.1) | 3.99 (1.53, 10.37) | 4.33 (1.61, 11.59) |
| [0.655] | [0.896] | |||
*
Odds ratio adjusted for age, gender, race, and body mass index at baseline
AUC = area under the curve, n= number, OR= Odds Ratio, CI= confidence interval
KL= Kellgren-Lawrence
MCP= metacarpophalangeal joint, PIP= proximal interphalangeal joint, DIP= distal interphalangeal joint
ǂ
Levels combined for analysis due to low numbers in higher levels.