Table 1.

A summary of the distribution of points and the weights that were affixed to individual categories of the CNS TAP tool.

CNS TAP Tool
	Description of Points	Weight	Range of Points
Pre-Clinical Data (in vitro)	0 = No data 1 = Activity against any cell type 2 = Activity against primary CNS tumor cell type	2	0 to 4
Pre-Clinical Data (in vivo)	0 = No data 1 = Activity against cells grafted into the flank 2 = Activity against orthotopic cells or cells grafted into the brain	3	0 to 6
Phase I Safety Data	0 = No data 1 = Ongoing pediatric clinical trial 2 = Published phase I trial with phase I dosing	3	0 to 6
CNS Data with Response	−2 = Evidence of lack of positive response of primary CNS tumors −1 = Evidence of lack of positive response of brain metastasis 0 = No data 1 = Evidence of positive response of a brain metastasis 2 = Evidence of positive response of a primary CNS tumor	5	−10 to 10
Brain Penetration	0 = Insufficient CNS penetration 1 = < 5% CNS penetration but Cmax above IC50 2 = > 5% CNS penetration and Cmax above IC50	5	0 to 10
FDA Approval	0 = No FDA approval 1 = FDA approval	10	0 to 10
Clonality/variant allele fraction (%)	0 = Pathway is non-dominant mutation 1 = Pathway is dominant mutation	5	0 to 5
Variant Tier Score	0 = Tier IV 1 = Tier III 2 = Tier I or Tier II	3	0 to 6
Relevant Clinical Trial	0 = No clinical trial considered 2 = Clinical trial is available that the patient is eligible for and willing to travel to	10	0 to 20