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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: Stem Cells. 2017 Nov 27;36(3):392–405. doi: 10.1002/stem.2742

Figure 6.

Figure 6

Activation of RA-signaling in damaged retinas stimulated the neuronal differentiation and suppressed the glial differentiation of MGPC-progeny. Eyes were injected with 500 nmol NMDA at P7, EdU at P9, vehicle+EdU (control) or RA+EdU or RA+liarozole+EdU (treated) at P10 and P11, and tissues harvested at P15.

Sections of the retina were labeled for EdU-incorporation (red) and antibodies to HuC/D (green) or GS (green). Arrows indicate the nuclei of EdU-labeled neurons or glia.

The box plots illustrate the mean, upper extreme, lower extreme, upper quartile and lower quartile (n=6 animals). Significance of difference (*p<0.05) was determined by using a Mann-Whitney U test. Arrows indicate the nuclei of MGPCs. The calibration bar in panels b, c,d represents 50 μm. Abbreviations: INL – inner nuclear layer, IPL – inner plexiform layer, GCL – ganglion cell layer, ONL – outer nuclear layer.