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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2018 Feb 1;38(3):622–635. doi: 10.1161/ATVBAHA.117.310605

Figure 1.

Figure 1

Transmission electron micrographs at two magnifications show structural changes in pulmonary artery endothelial cells of rats exposed for 48 hours to normoxia or hyperoxia in vivo. Lower power studies demonstrated scattered separation of PECs (identified with red asterix and “EC”) from underlying basement membrane in hyperoxia samples, but not normoxic ones. At higher power, the mitochondrial cristae are visible in cells maintained in normoxia, but are disrupted or absent in hyperoxic specimens (see red arrows with “mito” label).