Table 5.

Ortho-substituted benzoic acid derivatives of 5.

Compd	Z	RARα rel EC50a	β/α ratiob	γ/α ratiob
5	H	24	80	>12,500
17	F	25	80	>80
18	CH3	0.9	82	151
19	OH	33c	37	149
20	Cl	151	64	>50
21	CF3	1.7c	1.5	11

^a,b and ^c see Table 1.