Figure 1.

Angiotensin II inhibits T-type Ca²⁺ channels via the AT₁ receptor in cerebral arterial smooth muscle cells. (A and B) Representative traces, averaged I-V plots, and voltage dependence of activation and steady state inactivation of whole cell T-type current prior to and following Ang II application (100 nM) (n = 8). (C and D) Representative trace and average I-V plot of the T-type current in cells treated with losartan (1 µM) and then Ang II (n = 8). (E) Peak T-type current (pA/pF) at 5 min intervals under control condition and following treatment with losartan ± Ang II (n = 8). All recordings were performed in the presence of 200 nM nifedipine and using Ba²⁺ as a charge carrier. *Denotes significant difference compared to control (*P < 0.05, paired t test).