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. 2018 Feb 22;8:3453. doi: 10.1038/s41598-018-21492-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Morphology of the villous stroma of intermediate villi in preeclampsia. (A) Placental villi in preeclampsia. Sludged erythrocytes in the vascular lumen. Semithin section, ×400 (Methylene blue staining). (В) Stellate telocyte-like cells (Tc) are located near blood vessels. Slugged erythrocytes in the blood vessel lumen. The stroma contains collagen fibres and multiple vacuoles are seen in the syncytiotrophoblasts. Erythrocytes are in the lumen of the vessel (Er). Electron microphotograph, x4800. (C) Areas of telocyte-like cells form pseudo-stromal channels in mature intermediate villi. Semithin section, ×400 (Methylene blue staining) (areas with stromal channels are denoted with asterisks). (D) In the fibrotic villi stroma, telocyte-like cells (average diameter 3.25 0.6 μm) are seen due to their processes (diameter averages 0.28 ± 0.1 μm), which limit the pseudo-stromal channels. Formed vessels are shown nearby in stroma (areas with stromal channels denoted with asterisks). Electron microphotograph, ×1400. (E) Macrophages (M) with multi-lobed nuclei and multiple vacuoles. Semithin section, ×400. (F) Macrophages (M) with vacuoles. Electron microphotograph, ×4800. (G) Macrophages (M) with residual bodies. Electron microphotograph, ×4800.