Table 1.

Summary of molecular interactions between LRRK2 and FADD.

Interacting atom	Residue	Residue number	Interaction	Distance	E (kcal/mol)
Interactions between LRRK2 and the FADD DD monomers
NE2	ASP	185	H-donor	2.61	−1.8
NZ	ASP	175	H-donor	2.44	5.1
NZ	GLU	179	H-donor	2.26	99.8
O	GLN	182	H-acceptor	3.25	−2.0
NZ	GLU	179	ionic	2.26	−11.9
5-ring	GLN	182	pi-H	3.96	−0.6
Intra LRRK2 interactions (with adjacent ARM repeats)
N	GLN	536	H-donor	2.63	−5.2
N	ASN	540	H-donor	3.17	−2.9
OD1	GLN	536	H-acceptor	2.49	3.7
OD2	LYS	539	H-acceptor	2.27	103.4
ND1	ASN	540	H-acceptor	3.59	−0.7
O	ALA	548	H-acceptor	2.91	−1.4
OD2	LYS	539	ionic	2.27	−11.7