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. 2018 Feb 22;8:3500. doi: 10.1038/s41598-018-21891-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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HIF-1α deficiency in CD11c⁺ cells results in stronger Th1 responses in the bone marrow. Hif-1α^flox/floxCd11c-Cre⁻ (WT) and Hif-1α^flox/floxCd11c-Cre⁺ (KO) mice were infected with 2 × 10⁷ LV9 amastigotes intravenously. (a) Graph represents the frequency and (b) absolute numbers of bone marrow CD4 T cells. (c) Representative FACS plots for IFNγ⁺CD4 T cells of Hif-1α^flox/floxCd11c-Cre⁻ (upper panels) and Hif-1α^flox/floxCd11c-Cre⁺ mice (lower panels) in the bone marrow. (d) Percentage and (e) mean fluorescence intensity (MFI) of IFNγ⁺CD4 T cells in the bone marrow. Frequency (f) and numbers (g) of IFNγ⁺IL-10⁺ double producing CD4 T cells; percentage (h) and numbers (i) of IL-10⁺ single producers CD4 T cells in the bone marrow over the course of infection. All data represent mean ± SEM of one of 3 independent experiments, n = 4.