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. 2018 Feb 22;8:3500. doi: 10.1038/s41598-018-21891-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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HIF-1α expression alters DC functions. Mice were infected with 2 × 10⁷ amastigotes intravenously. Real-time PCR analysis of HIF-1α (a), IL-12p35 (b), IL-12p40 (c), IL-10 (d), and TNF (e) expression in splenic DCs from Hif-1α^flox/floxCd11c-Cre⁻ (WT) and Hif-1α^flox/floxCd11c-Cre⁺ (KO) mice over the course of infection. Gene fold increase was referred to Hprt reporter gene. All data represent mean ± SEM combined from 2 independent experiments.