Table 1.
Results of the Polygenic score analyses.
| Threshold | P | R2 | FDR P | Phenotype |
|---|---|---|---|---|
| 0.01 | 9.94E-01 | 1.37E-08 | 9.94E-01 | Anorexia |
| 0.05 | 9.90E-01 | 3.40E-08 | 9.94E-01 | Anorexia |
| 0.1 | 3.75E-01 | 1.70E-04 | 6.50E-01 | Anorexia |
| 0.15 | 2.83E-01 | 2.49E-04 | 5.72E-01 | Anorexia |
| 0.2 | 4.63E-01 | 1.17E-04 | 7.25E-01 | Anorexia |
| 0.5 | 5.69E-01 | 7.03E-05 | 8.34E-01 | Anorexia |
| 0.8 | 4.47E-01 | 1.25E-04 | 7.22E-01 | Anorexia |
| 1 | 4.36E-01 | 1.32E-04 | 7.22E-01 | Anorexia |
| 0.01 | 7.90E-01 | 1.54E-05 | 9.56E-01 | Autism |
| 0.05 | 5.23E-01 | 8.86E-05 | 8.01E-01 | Autism |
| 0.1 | 7.06E-01 | 3.08E-05 | 9.08E-01 | Autism |
| 0.15 | 7.52E-01 | 2.17E-05 | 9.50E-01 | Autism |
| 0.2 | 8.08E-01 | 1.27E-05 | 9.56E-01 | Autism |
| 0.5 | 9.30E-01 | 1.69E-06 | 9.74E-01 | Autism |
| 0.8 | 8.23E-01 | 1.08E-05 | 9.56E-01 | Autism |
| 1 | 8.08E-01 | 1.27E-05 | 9.56E-01 | Autism |
| 0.01 | 3.90E-02 | 9.24E-04 | 1.65E-01 | ADHD |
| 0.05 | 1.33E-01 | 4.88E-04 | 4.86E-01 | ADHD |
| 0.1 | 1.83E-01 | 3.85E-04 | 4.86E-01 | ADHD |
| 0.15 | 1.28E-01 | 5.03E-04 | 4.86E-01 | ADHD |
| 0.2 | 1.66E-01 | 4.15E-04 | 4.86E-01 | ADHD |
| 0.5 | 1.53E-01 | 4.43E-04 | 4.86E-01 | ADHD |
| 0.8 | 1.74E-01 | 4.01E-04 | 4.86E-01 | ADHD |
| 1 | 1.69E-01 | 4.11E-04 | 4.86E-01 | ADHD |
| 0.01 | 8.52E-01 | 7.54E-06 | 9.59E-01 | Bipolar disorder |
| 0.05 | 6.31E-01 | 5.01E-05 | 8.68E-01 | Bipolar disorder |
| 0.1 | 3.68E-01 | 1.76E-04 | 6.50E-01 | Bipolar disorder |
| 0.15 | 2.43E-01 | 2.96E-04 | 5.47E-01 | Bipolar disorder |
| 0.2 | 2.23E-01 | 3.23E-04 | 5.35E-01 | Bipolar disorder |
| 0.5 | 1.89E-01 | 3.73E-04 | 4.86E-01 | Bipolar disorder |
| 0.8 | 1.86E-01 | 3.79E-04 | 4.86E-01 | Bipolar disorder |
| 1 | 1.99E-01 | 3.57E-04 | 4.94E-01 | Bipolar disorder |
| 0.01 | 8.42E-01 | 8.59E-06 | 9.59E-01 | Depression |
| 0.05 | 8.98E-01 | 3.56E-06 | 9.74E-01 | Depression |
| 0.1 | 8.20E-01 | 1.13E-05 | 9.56E-01 | Depression |
| 0.15 | 5.88E-01 | 6.36E-05 | 8.34E-01 | Depression |
| 0.2 | 6.41E-01 | 4.71E-05 | 8.68E-01 | Depression |
| 0.5 | 9.71E-01 | 2.88E-07 | 9.94E-01 | Depression |
| 0.8 | 9.28E-01 | 1.76E-06 | 9.74E-01 | Depression |
| 1 | 9.33E-01 | 1.51E-06 | 9.74E-01 | Depression |
| 0.01 | 2.95E-01 | 2.38E-04 | 5.74E-01 | Schizophrenia |
| 0.05 | 1.38E-01 | 4.76E-04 | 4.86E-01 | Schizophrenia |
| 0.1 | 1.46E-01 | 4.59E-04 | 4.86E-01 | Schizophrenia |
| 0.15 | 2.57E-01 | 2.78E-04 | 5.61E-01 | Schizophrenia |
| 0.2 | 2.81E-01 | 2.52E-04 | 5.72E-01 | Schizophrenia |
| 0.5 | 2.86E-01 | 2.47E-04 | 5.72E-01 | Schizophrenia |
| 0.8 | 3.19E-01 | 2.15E-04 | 5.89E-01 | Schizophrenia |
| 1 | 3.15E-01 | 2.19E-04 | 5.89E-01 | Schizophrenia |
| 0.01 | 7.06E-04 | 2.48E-03 | 4.62E-03 | Cognitive empathy |
| 0.05 | 8.08E-04 | 2.43E-03 | 4.85E-03 | Cognitive empathy |
| 0.1 | 3.38E-04* | 2.78E-03 | 2.43E-03 | Cognitive empathy |
| 0.15 | 1.34E-04* | 3.16E-03 | 1.07E-03 | Cognitive empathy |
| 0.2 | 2.78E-03 | 1.94E-03 | 1.25E-02 | Cognitive empathy |
| 0.5 | 1.87E-03 | 2.10E-03 | 8.98E-03 | Cognitive empathy |
| 0.8 | 1.15E-03 | 2.29E-03 | 6.37E-03 | Cognitive empathy |
| 1 | 1.43E-03 | 2.20E-03 | 7.35E-03 | Cognitive empathy |
| 0.01 | 5.75E-01 | 6.82E-05 | 8.34E-01 | Empathy |
| 0.05 | 8.79E-01 | 5.01E-06 | 9.74E-01 | Empathy |
| 0.1 | 4.51E-01 | 1.23E-04 | 7.22E-01 | Empathy |
| 0.15 | 2.39E-01 | 3.00E-04 | 5.47E-01 | Empathy |
| 0.2 | 3.79E-01 | 1.68E-04 | 6.50E-01 | Empathy |
| 0.5 | 5.91E-01 | 6.27E-05 | 8.34E-01 | Empathy |
| 0.8 | 6.69E-01 | 3.96E-05 | 8.76E-01 | Empathy |
| 1 | 6.51E-01 | 4.44E-05 | 8.68E-01 | Empathy |
| 0.01 | 2.13E-05* | 4.56E-03 | 1.92E-04 | Cognitive aptitude |
| 0.05 | 3.83E-09* | 7.50E-03 | 5.52E-08 | Cognitive aptitude |
| 0.1 | 1.87E-08* | 6.83E-03 | 1.92E-07 | Cognitive aptitude |
| 0.15 | 6.00E-09* | 7.31E-03 | 7.20E-08 | Cognitive aptitude |
| 0.2 | 3.54E-09* | 7.53E-03 | 5.52E-08 | Cognitive aptitude |
| 0.5 | 1.21E-09* | 7.98E-03 | 4.13E-08 | Cognitive aptitude |
| 0.8 | 1.72E-09* | 7.83E-03 | 4.13E-08 | Cognitive aptitude |
| 1 | 1.61E-09* | 7.86E-03 | 4.13E-08 | Cognitive aptitude |
*Indicates significant polygenic score association after Bonferroni correction (P < 6.94 × 10−4).