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. 2018 Feb 22;8:3495. doi: 10.1038/s41598-018-21409-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Localization of Notch-ligands expressing cells in the spleen. (A) DLL1⁺ cells in extrafollicular sites of Lgals3^+/+ mice. (B) DLL1⁺ cells atypically distributed on Lgals3^−/− mice. (C) DLL4⁺ cells in well defined sites in Lgals3^+/+ mice and (D) disorganized in Lgals3^−/− mice. (E) JAG1⁺ cells on extrafollicular regions of Lgals3^+/+ mice and randomly distributed in Lgals3^−/− mice (F). (G) Percentage of splenic cells according positivity to DLL1, DLL4 and JAG1. Dot plot graphs by flow cytometry identify hematopoietic (CD45⁺) cells and stromal (CD45⁻) cells in both Lgals3^+/+ and Lgals3^−/− mice (H and I, in R3, respectively). Histograms indicate the intensity of expression of DLL1 (J), DLL4 (K) and JAG1 (L) in both groups of mice. n = 5 mice per group. Magnification: (A–F) 100×; inserts 400×; DLL1 = Delta-like 1, DLL4 = Delta-like 4 and JAG1 = Jagged-1. (*) Indicates p < 0.05. (***) Indicates p < 0.01.