Table 1.
Summary pIC50 values (mean ± SE (N)) for (RS)-, (R)- and (S)-citalopram on platelet aggregation, static adhesion to collagen, TxB2 generation, ATP and ADP release, site-specific protein tyrosine phosphorylation and 5-HT uptake.
| Function | Agonist/ligand | pIC50 (mean ± SE (N)) | ||
|---|---|---|---|---|
| (RS) | (R) | (S) | ||
| Aggregation | Collagen | 4.31 ± 0.21 (7) | 4.29 ± 0.36 (7) | 4.25 ± 0.21 (7) |
| U46619 | 4.15 ± 0.27 (6) | 4.12 ± 0.22 (6) | 4.20 ± 0.29 (6) | |
| Adhesion | Collagen | 3.76 ± 0.02 (9) | 3.77 ± 0.05 (4) | 3.72 ± 0.01 (4) |
| CRP | 3.78 ± 0.04 (8) | 3.81 ± 0.05 (4) | 3.74 ± 0.01 (4) | |
| Fibrinogen | 4.00 ± 0.07 (9) | 3.92 ± 0.04 (4) | 3.92 ± 0.05 (4) | |
| GFOGER | 3.97 ± 0.03 (9) | 4.02 ± 0.05 (4) | 3.95 ± 0.03 (4) | |
| TxB2 synthesis | Collagen | 4.77 ± 0.08 (6) | 4.68 ± 0.04 (6) | 4.70 ± 0.09 (6) |
| Release (ATP) Release (ADP) | Collagen Collagen | 4.54 ± 0.06 (5) 4.51 ± 0.06 (5) | ||
| PLCγ2 (Y1217) SFK (Y416) LAT (Y200) | CRPXL CRPXL CRPXL | 4.28 ± 0.03 (5) 4.24 ± 0.03 (4) 3.77 ± 0.03 (5) | ||
| 5-HT uptake | 5-HT | 8.34 ± 0.05 (13) | 7.37 ± 0.05 (13) | 8.60 ± 0.05 (13) |