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. 2018 Feb 22;8:3507. doi: 10.1038/s41598-018-21574-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Absence of the P2X7R renders osteoclast precursor cells sensitive to exogenous stimuli. Precursor cells from bone marrow aspirates of BALB/cJ P2X7R^+/+ and BALB/cJ P2X7R^−/− were differentiated on dentine and TRAP stained. In normal (N) conditions the (A) total number of resorbing osteoclasts, (B) total resorption and (C) the resorptive ability (resorption/resorbing osteoclast) was determined. In modified (M) conditions the (D) total number of resorbing osteoclasts, (E) total resorption and (F) response to modified conditions on the resorptive ability of osteoclasts (expressed as a fold change of the mean resorption/resorbing osteoclast of the normal conditions (N) in either genotype) was determined. Values are mean ± SEM, n = 3 repeat cultures containing a total of 11 dentine discs. *p<0.05 **p<0.01, ***p<0.001, unpaired parametric t-test or non-parametric Mann-Whitney test as appropriate. (G) Representative images show non-resorbing (black arrows) and resorbing (white arrows) osteoclasts and resorption trails (white stars) excavated by the cells on dentine in both normal and modified conditions. Scale bar = 500 µm.