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. 2018 Feb 22;8:3459. doi: 10.1038/s41598-018-21516-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Quercetin (A) and (B) Green tea reduce tumor growth in HL60 xenografts. (C) Quercetin (D) and Green tea tumor volume after 21 days of treatment. The body weights of the xenograft mice treated with Quercetin (E) and Green tea (F). NOD/SCID mice with HL-60 tumors were treated or not with quercetin (120 mg/kg) once every 4 days or green tea (100 mg/kg) every day during 21 days. Every 7 days the tumor volumes were evaluated according to the following formula: tumor volume (mm³) ¼ (length × width2)/2. The control group received equal amounts of vehicle solution, as indicated in Materials and Methods. (Values are means ± SD (mean of 6 mice/group); *P < 0.05.