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. 2018 Feb 22;9:766. doi: 10.1038/s41467-018-03119-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — Treatment of orthotopic breast cancer and inhibitory effects on lung metastasis. a Tumour volume changes and b Kaplan–Meier survival curves of the mice bearing orthotopic 4T1 breast tumours treated with different formulations after one injection (n = 8). c The numbers of tumour nodules present on the lung surface from each group. d Tumour coverage percentage in the lungs from each group. e Photo images of the orthotopic tumours harvested from the mice treated with different formulations. f H&E and Ki-67 staining of the tumour tissues from each group. g Representative images of the lungs excised from each group. The black circles denote the visually detected metastatic nodules in each lung tissue. h Histological examination of metastatic lesions in lung tissues from each group after H&E staining. i PET/CT images of the mice treated with different formulations at the 14th day post-injection. Arrows indicates possible metastatic tumours. The laser density was 0.5 W cm⁻², and the irradiation time was 5 min. Data are expressed as means ± s.e.m., ***P < 0.001