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. 2018 Jan 29;41(2):119–126. doi: 10.14348/molcells.2018.2235

Fig. 5. Overexpression of Espin rescues melanoma cells from miR-612-mediated anticancer activity.

Fig. 5

miR-612-overexpressing A375 cells were re-transfected with vector or Espin-expressing plasmid and tested for gene expression, proliferation, invasion, and tumorigenesis. (A) Western blot analysis of ESPIN protein expression. (B) Cell proliferation assessed by BrdU incorporation assay. (C) Cell invasion determined by Transwell invasion assay. (D) miR-612-overexpressing A375 cells were re-transfected with vector or Espin-expressing plasmid were subcutaneously injected to mice and tumor growth was measured. *P < 0.05 vs. the vector group.