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The Hippo pathway regulates YAP/TAZ activation in cancer cells through a wide range of upstream stimuli, such as extracellular ligands, mechanotransduction, environmental stress, energy stress, and cell-cell contact. Aberrant activation of YAP/TAZ via dysregulation of the Hippo pathway results in tumorigenesis and confers cancer stem cell traits that lead to anoikis resistance, EMT, drug resistance, and metastasis.
