FIG 4.

Binding of Z-EDI and Z-EDIII with remote (A and B) and recent (C and D) convalescent-phase sera from patients infected with ZIKV and/or DENV. Primary (filled symbols) and secondary (unfilled symbols) human serum samples were diluted 1:20, and the IgG antibodies bound to Z-EDI (A and C) or Z-EDIII (B and D) were measured using a sandwich ELISA. Sera collected ≥12 weeks after infection were defined as remote infections, and sera collected within the first 12 weeks were considered to represent recent infections. Statistical significances are indicated at the top of the graphs (Mann-Whitney U test). P values of <0.0001 were considered statistically significant. The horizontal lines represent the means.