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. 2018 Feb 18;11(2):183–188. doi: 10.18240/ijo.2018.02.01

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International Journal of Ophthalmology Press

PMC Copyright notice

VIP antagonist treatment increased the clinical scores of BALB/c mice (A) after 3 and 5d infection. Photographs showed worsened disease after VIP antagonist treatment (C) compared with PBS (B) control after 3d infection. Relative mRNA levels of IL-1β (D) and TNF-α (E) were increased in VIP antagonist treated cornea at 3d p.i. The protein expression of IL-1β (G) and TNF-α (H) were upregulated in VIP antagonist treated cornea after 3 and 5d infection. IL-10 mRNA (F) was downregulated in VIP antagonist treated cornea compared with PBS control at 3d p.i. The protein levels of IL-10 (I) were decreased in VIP antagonist treated cornea after 3 and 5d infection. ^aP<0.01, ^bP<0.05.