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. 2018 Feb 18;11(2):287–295. doi: 10.18240/ijo.2018.02.18

Table 2. Baseline data of the included clinical trials in the Meta-analysis.

Included study (year) Sample size Interventions Baseline characteristics
Age (y) Diabetes duration (y) VA HbA1c (%) TC LDL-C HDL-C TG
Chung et al 2017[11] 70 Statin 58.1 (11.6) 12.4 (8.0) NA 8.1 (1.7) 4.4 (2.6) 2.1 (0.8) 1.1 (0.3) 1.9 (1.4)
40 No-statin 52.3 (12.2) 8.6 (8.2) NA 8.0 (1.5) 4.4 (1.5) 3.0 (1.3) 1.1 (0.3) 2.1 (1.5)
ACCORDION et al 2016[15] 399 Fibrate plus simvastatin 61.8 (5.8) 9.8 (6.5) NA 8.2 (1.0) NA 2.79 (0.78) 0.98 (0.19) 2.1 (1.14)
363 Placebo plus simvastatin 61.1 (5.6) 9.4 (6.6) NA 8.1 (0.9) NA 2.84 (0.87) 1.0 (0.19) 2.06 (1.18)
Keech et al 2007[21] 4895 Fenofibrate NA NA NA NA 5.04 3.07 1.1 NA
4900 Placebo NA NA NA NA 5.04 3.07 1.1 NA
512 Fenofibrate NA NA NA NA 5.04 3.07 1.1 NA
500 Placebo NA NA NA NA 5.04 3.07 1.1 NA
Gupta et al 2004[22] 15 Atorvastatin 55.53 (8.29) 10.99 (5.42) NA 8.38 5.95 (0.96) 3.29 (0.56) NA 2.13 (1.05)
15 No-lipid lowering agents 52.73 (7.27) 14.07 (4.36) NA 8.32 6.07 (1.78) 3.16 (0.75) NA 2.41 (1.52)
Sen et al 2002[23] 25 Simvastatin 54.9 (7.8) NA NA 7.4 (0.14) 5.8 (0.69) 4.1 (0.65) 1 (0.1) 1.4 (0.6)
25 Placebo 53.0 (10.2) NA NA 7.3 (0.26) 5.5 (0.45) 4 (0.53) 1 (0.13) 1.3 (0.31)
Chew et al 2010[24] 806 Fibrate plus simvastatin 61.9 (6.2) 9.7 (6.8) 76.2 (9.7) 8.2 (1.0) NA 2.49 (0.76) 0.99 (0.20) 2.14 (1.25)
787 Placebo plus simvastatin 61.5 (6.5) 9.8 (7.2) 76.2 (10.7) 8.2 (1.0) NA 2.50 (0.77) 0.99 (0.20) 2.12 (1.27)
Massin et al 2014[25] 52 Fenofibrate 62.6 (6.3) 14.3 0.28 (0.27) 7.8 (1.1) NA 3.16 (1.07) 1.23 (0.33) 2.25 (1.29)
50 Placebo 60.6 (8.8) 13.3 0.23 (0.27) 8.0 (1.0) NA 3.05 (1.16) 1.21 (0.34) 2.18 (0.92)

Data shown was the mean (SD) of each parameter except for the study by Keech et al[21] that only provided the mean. TC: Total cholesterol; TG: Triglyceride; LDL-C: Low-density lipoprotein cholesterol; HDL: High-density lipoprotein cholesterol. In three articles, mg/dL instead of mmol/L was used, therefore, interchange of units was performed according the following calculation: TC: 100 mg/dL=2.58 mmol/L, TG: 100 mg/dL=1.13 mmol/L, LDL: 100 mg/dL=2.59 mmol/L, HDL: 100 mg/dL= 2.58 mmol/L. Mixed=D1M and D2M. Baseline data of the first article[11] was exchanged from the table in the paper (Table 2: Baseline characteristics of participants requiring or not requiring laser treatment during the study).

mean±SD