Table 2. Baseline data of the included clinical trials in the Meta-analysis.
| Included study (year) | Sample size | Interventions | Baseline characteristics |
|||||||
| Age (y) | Diabetes duration (y) | VA | HbA1c (%) | TC | LDL-C | HDL-C | TG | |||
| Chung et al 2017[11] | 70 | Statin | 58.1 (11.6) | 12.4 (8.0) | NA | 8.1 (1.7) | 4.4 (2.6) | 2.1 (0.8) | 1.1 (0.3) | 1.9 (1.4) |
| 40 | No-statin | 52.3 (12.2) | 8.6 (8.2) | NA | 8.0 (1.5) | 4.4 (1.5) | 3.0 (1.3) | 1.1 (0.3) | 2.1 (1.5) | |
| ACCORDION et al 2016[15] | 399 | Fibrate plus simvastatin | 61.8 (5.8) | 9.8 (6.5) | NA | 8.2 (1.0) | NA | 2.79 (0.78) | 0.98 (0.19) | 2.1 (1.14) |
| 363 | Placebo plus simvastatin | 61.1 (5.6) | 9.4 (6.6) | NA | 8.1 (0.9) | NA | 2.84 (0.87) | 1.0 (0.19) | 2.06 (1.18) | |
| Keech et al 2007[21] | 4895 | Fenofibrate | NA | NA | NA | NA | 5.04 | 3.07 | 1.1 | NA |
| 4900 | Placebo | NA | NA | NA | NA | 5.04 | 3.07 | 1.1 | NA | |
| 512 | Fenofibrate | NA | NA | NA | NA | 5.04 | 3.07 | 1.1 | NA | |
| 500 | Placebo | NA | NA | NA | NA | 5.04 | 3.07 | 1.1 | NA | |
| Gupta et al 2004[22] | 15 | Atorvastatin | 55.53 (8.29) | 10.99 (5.42) | NA | 8.38 | 5.95 (0.96) | 3.29 (0.56) | NA | 2.13 (1.05) |
| 15 | No-lipid lowering agents | 52.73 (7.27) | 14.07 (4.36) | NA | 8.32 | 6.07 (1.78) | 3.16 (0.75) | NA | 2.41 (1.52) | |
| Sen et al 2002[23] | 25 | Simvastatin | 54.9 (7.8) | NA | NA | 7.4 (0.14) | 5.8 (0.69) | 4.1 (0.65) | 1 (0.1) | 1.4 (0.6) |
| 25 | Placebo | 53.0 (10.2) | NA | NA | 7.3 (0.26) | 5.5 (0.45) | 4 (0.53) | 1 (0.13) | 1.3 (0.31) | |
| Chew et al 2010[24] | 806 | Fibrate plus simvastatin | 61.9 (6.2) | 9.7 (6.8) | 76.2 (9.7) | 8.2 (1.0) | NA | 2.49 (0.76) | 0.99 (0.20) | 2.14 (1.25) |
| 787 | Placebo plus simvastatin | 61.5 (6.5) | 9.8 (7.2) | 76.2 (10.7) | 8.2 (1.0) | NA | 2.50 (0.77) | 0.99 (0.20) | 2.12 (1.27) | |
| Massin et al 2014[25] | 52 | Fenofibrate | 62.6 (6.3) | 14.3 | 0.28 (0.27) | 7.8 (1.1) | NA | 3.16 (1.07) | 1.23 (0.33) | 2.25 (1.29) |
| 50 | Placebo | 60.6 (8.8) | 13.3 | 0.23 (0.27) | 8.0 (1.0) | NA | 3.05 (1.16) | 1.21 (0.34) | 2.18 (0.92) | |
Data shown was the mean (SD) of each parameter except for the study by Keech et al[21] that only provided the mean. TC: Total cholesterol; TG: Triglyceride; LDL-C: Low-density lipoprotein cholesterol; HDL: High-density lipoprotein cholesterol. In three articles, mg/dL instead of mmol/L was used, therefore, interchange of units was performed according the following calculation: TC: 100 mg/dL=2.58 mmol/L, TG: 100 mg/dL=1.13 mmol/L, LDL: 100 mg/dL=2.59 mmol/L, HDL: 100 mg/dL= 2.58 mmol/L. Mixed=D1M and D2M. Baseline data of the first article[11] was exchanged from the table in the paper (Table 2: Baseline characteristics of participants requiring or not requiring laser treatment during the study).
mean±SD