Table 1. Molecular comparison of H5 avian influenza viruses and similar isolates, South Korea, December 2017 (n = 8).
| Virusesa | HA clade | HA sequence (aa) | HA deletion |
NA stalk deletion | NS1 | PB2 sequence at aa | Expression of PB1-F2 protein | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cleavage site | Receptor binding sites | Deletion of aa 80–84 | aa residue at | |||||||||||||||
| 335–348b | 158 | 193 | 222 | 224 | 226 | 227 | 228 | 318 | 133 | 49–68 | 92 | C-term | 627 | 701 | ||||
| AP/Korea/W612/17 | 2.3.4.4 | REKRRK__ /G | N | N | Q | N | Q | R | G | T | No | No | No | D | GSEV | E | D | Yes |
| PC/Belgium/1017/17 | 2.3.4.4 | REKRRK__ /G | N | N | Q | N | Q | R | G | T | No | No | No | D | GSEV | E | D | Yes |
| TD/Germany/AR8459-L01988/16 | 2.3.4.4 | REKRRK__ /G | N | N | Q | N | Q | R | G | T | No | No | No | D | GSEV | E | D | Yes |
| EM/Korea/W541/16 | 2.3.4.4 | RERRRK__/G | N | N | Q | N | Q | Q | G | T | Yes | Yes | Yes | E | ESEV | E | D | Yes |
| CT/Korea/W555/17 | 2.3.4.4 | REKRRK__ /G | N | N | Q | N | Q | R | G | T | No | No | No | D | GSEV | E | D | Yes |
| MD/Korea/W452/14 | 2.3.4.4 | RERRRK__/G | N | N | Q | N | Q | R | G | T | No | No | No | D | ESEVRG | E | D | Yes |
| BDk/Korea/Gochang1/14 | 2.3.4.6 | REKRRK __/G | N | N | Q | N | Q | R | G | T | No | No | No | D | ESEV | E | D | Yes |
| EM/Korea/W149/06 | 2.2 | GERRRKKR/G | N | K | K | N | Q | S | G | T | No | Yes | Yes | D | ESKV | K | D | Yes |
aa: amino acid; AP: Anas platyrhynchos; BDk: breeder duck; CT: common teal; C-term: 4 aa sequence at the C-terminal end; EM: environment; HA: haemaggutinin; MD: mallard duck; NA: neuraminidase; PC: peacock; RBS: receptor binding site; TD: tufted duck.
a The isolate in bold was the 2017 Korean highly pathogenic avian influenza H5N6 viruses examined in this study.
b H3 numbering.