Table 1.

Comparison of leukogram and macroscopic findings among different HTLV viruses

Virus used to infect human umbilical cord stem cells	Cell count (×103/µL) (no. of mice)					No. of mice affected/ no. of mice evaluated
	WBC	Lymphocytes	Macrophages	Neutrophils	Eosinophils	Atypical cells	Splenomegaly or lymphadenopathy
None	2.7 ± 1.3 (7)	0.6 ± 0.4	0.2 ± 0.2	1.9 ± 1.0	0.1 ± 0.1	None	None
HTLV1 (MT2)	52.0 ± 36.5 (5)	14.0 ± 25.7	9.8 ± 7.2	26.2 ± 17.2	2.0 ± 1.2	5/10	4/6
HTLV1 (ACH.2)	5.9 ± 4.9 (6)	2.2 ± 2	0.7 ± 0.5	2.7 ± 2.0	0.2 ± 0.4	3/6	2/5
HTLV2 (729.wt.)	12.2 ± 13.6 (5)	2.9 ± 3	2.5 ± 3	9.5 ± 9.9	0.8 ± 1.0	1/5	3/5
HTLV1–Env2	7.0 ± 8.1 (5)	1.9 ± 3.5	1.3 ± 2.3	3.9 ± 2.8	0.1 ± 0.1	1/6	2/6
HTLV2–Env1	2.5 ± 1.3 (6)	0.8 ± 0.5	0.3 ± 0.1	1.3 ± 0.7	0.1 ± 0.1	1/5	0/5

Mice were euthanized according to clinical signs (early removal criteria) at the respective time points (see Table 2). WBC counts were performed at euthanasia and included both human and mouse cells.