Figure 9.

RSV infection attenuates the eosinophil response after challenge with HDM allergen. BAL cytology of cotton rats infected with 10⁵ TCID₅₀ RSV intranasally (RSV only), treated with 2 doses of the allergen HDM (HDM only), or both treated with allergen and infected with RSV (HDM+RSV). Cotton rats that received HDM treatment were sensitized through intraperitoneal injection on day 0 and challenged intranasally on day 8. RSV infections were performed intranasally on day 7. BAL fluid was collected on day 11, at 4 d after RSV inoculation. Bars represent mean values (n = 4–8 cotton rats per group); error bar, 1 SD. Value differs significantly (‡, adjusted P < 0.001; §, adjusted P < 0.0001; Welch t test, Holm–Sidak correction) from that for the RSV-only group or (†, adjusted P < 0.01;Welch t test, Holm–Sidak correction) from the HDM-only group.