Table 1. Baseline Characteristics of Patients With Recurrent OCSCC.
| Characteristic | No. (%) | ES (95% CI) | |
|---|---|---|---|
| Salvage Surgery (n = 39) |
No Salvage Surgery (n = 20) |
||
| At Time of Initial Diagnosis | |||
| Age, mean (SD), y | 62.1 (12.4) | 62.5 (10.9) | 0.37 (−5.98 to 6.73) |
| Male | 23 (59) | 16 (80) | 21.0 (−2.3 to 44.4) |
| Smoking history | |||
| Yes, >25 pack-years | 16 (42) | 7 (41) | −0.9 (−29.1 to 27.2) |
| Yes, <25 pack-years | 4 (11) | 2 (12) | 1.2 (−16.9 to 19.4) |
| No | 18 (47) | 8 (47) | −0.3 (−28.9 to 28.2) |
| Alcohol use | |||
| <21 Drinks/wk | 31 (86) | 15 (79) | −7.2 (−28.7 to 14.4) |
| >21 Drinks/wk | 5 (14) | 4 (21) | 7.2 (−14.4 to 28.7) |
| Initial T category | |||
| T1 | 19 (49) | 2 (10) | −38.7 (−59.2 to −18.3) |
| T2 | 9 (23) | 5 (25) | 1.9 (−21.2 to 25.1) |
| T3 | 2 (5) | 4 (20) | 14.9 (−4.0 to 33.7) |
| T4a | 9 (23) | 9 (45) | 21.9 (−3.6 to 47.4) |
| Initial N category | |||
| N0 | 30 (77) | 6 (30) | −46.9 (−71.0 to −22.9) |
| N1 | 2 (5) | 5 (25) | 19.9 (−0.3 to 40.1) |
| N2a | 1 (3) | 0 | −2.6 (−7.5 to 2.4) |
| N2b | 4 (10) | 8 (40) | 29.7 (6.3 to 53.2) |
| N2c | 2 (5) | 1 (5) | −0.1 (−11.9 to 11.7) |
| Initial treatment | |||
| Surgery alone | 28 (72) | 8 (40) | −31.8 (−57.5 to −6.1) |
| Surgery + RT/CRT | 11 (28) | 12 (60) | 31.8 (6.1 to 57.5) |
| At Time of Recurrence | |||
| Recurrence location | |||
| Alveolus | 8 (21) | 4 (20) | −0.5 (−22.1 to 21.1) |
| Buccal | 4 (10) | 1 (5) | −5.3 (−18.7 to 8.2) |
| Floor of mouth | 7 (18) | 0 | −18.0 (−30.0 to −5.9) |
| Retromolar trigone | 2 (5) | 1 (5) | −0.1 (−11.9 to 11.7) |
| Tongue | 14 (36) | 3 (15) | −20.9 (−42.6 to 0.8) |
| Other | 4 (10) | 11 (55) | 44.7 (21.0 to 68.5) |
| Salvage treatment | |||
| Any | 39 (100) | 11 (55) | −45.0 (−66.8 to −23.2) |
| Surgery alone | 24 (62) | 0 | −61.5 (−76.8 to −46.3) |
| Surgery + RT/CRT | 15 (38) | 0 | −38.5 (−53.7 to −23.2) |
| RT ± CT | 0 | 11 (55) | 55.0 (33.2 to 76.8) |
| None | 0 | 9 (45) | 45.0 (23.2 to 66.8) |
| Status | |||
| Alive, disease | 1 (3) | 1 (5) | 2.7 (−8.5 to 13.9) |
| Alive, no disease | 17 (44) | 1 (5) | −38.3 (−56.9 to −19.8) |
| Death, disease | 16 (41) | 15 (79) | 37.9 (14.0 to 61.9) |
| Death, no disease | 5 (13) | 2 (11) | −2.3 (−19.6 to 15.0) |
| Median follow-up, median (95% CI), y | 8.25 (5.50-9.08) | 6.33a | |
Abbreviations: CRT, chemotherapy; CT, chemotherapy; ES, effect size; OCSCC, oral cavity squamous cell carcinoma; RT, radiotherapy.
a
Calculation was based on 2 individuals in this group; therefore, no 95% CI could be calculated.