Table 2. OS in Patients Undergoing Salvage Surgery for Recurrent OCSCC.
| Variable | OS, HR (95% CI)a |
|---|---|
| At Initial Diagnosis | |
| Age, ≥62 vs <62 y | 3.20 (1.20-8.45) |
| Male | 1.49 (0.62-3.60) |
| Smoking history, yes vs no | 0.64 (0.27-1.52) |
| Alcohol use, >21 vs <21 drinks/wk | 1.64 (0.47-5.68) |
| Initial T category, T3-T4 vs T1-T2 | 5.50 (2.20-13.74) |
| Initial N category, N1-N2 vs N0 | 3.07 (1.15-8.20) |
| Primary treatment | |
| Surgery + CRT vs surgery | 2.37 (0.52-10.76) |
| Surgery + RT vs surgery | 8.64 (2.93-25.47) |
| Differentiation vs well | |
| Moderate/well-moderate | 1.32 (0.51-3.43) |
| Poor/moderate-poor | 0.87 (0.22-3.39) |
| Perineural invasion | 5.68 (1.89-17.03) |
| Vascular invasion | 7.85 (2.10-29.30) |
| Margin status | |
| Close, <3 mm vs negative | 0.71 (0.24-2.13) |
| Positive vs negative | 0.37 (0.05-2.80) |
| Extracapsular spread | 8.62 (2.09-35.49) |
| At the Time of Recurrence | |
| Smoking history, yes vs no | 0.75 (0.27-2.04) |
| Alcohol use, >21 vs <21 drinks/wk | 0.86 (0.31-2.41) |
| Recurrent T category, T3-T4 vs T1-T2 | 3.29 (1.31-8.25) |
| Recurrent N category, N1-N3 vs N0 | 1.57 (0.51-4.83) |
| Second treatment | |
| Surgery + RT/CRT vs surgery | 1.67 (0.69-4.03) |
| Site of recurrence, vs tongue | |
| Alveolus | 1.48 (0.95-4.84) |
| Buccal | 3.00 (0.74-12.24) |
| Floor of mouth | 2.53 (0.77-8.34) |
| Retromolar trigone | 1.64 (0.19-13.85) |
| Other | 0.78 (0.09-6.48) |
| Reconstruction | 2.51 (0.95-6.67) |
| Nodal disease | 2.29 (0.91-5.78) |
| Differentiation vs well | |
| Moderate/well-moderate | 1.44 (0.48-4.31) |
| Poor/moderate-poor | 3.63 (0.98-13.39) |
| Perineural invasion | 2.64 (1.05-6.66) |
| Lymphatic invasion | 3.69 (1.16-11.69) |
| Vascular invasion | 4.99 (1.67-14.94) |
| Margin status | |
| Close, <3 mm vs negative | 2.15 (0.77-6.02) |
| Positive vs negative | 5.22 (1.61-16.94) |
| Extracapsular spread | 1.94 (0.50-7.56) |
Abbreviations: CRT, chemoradiotherapy; HR, hazard ratio; OCSCC, oral cavity squamous cell carcinoma; OS, overall survival; RT, radiotherapy.
a
Univariate analysis using Cox proportional hazards regression models predictive of OS.