Table. Overall Survival Analysis by Lymph Node Status and Patient Characteristics.
| Variable | Univariable Analysis | Multivariable Analysis | ||
|---|---|---|---|---|
| HR (95%CI) | P Value | HR (95%CI) | P Value | |
| No. of resected nodes, quartilesa | ||||
| 1-14 | 1 [Reference] | <.001 | NA | NA |
| 15-24 | 0.94 (0.86-1.04) | |||
| 25-35 | 0.80 (0.72-0.89) | |||
| 36-90 | 0.88 (0.79-0.98) | |||
| No. of resected nodes | ||||
| ≤24 | 1 [Reference] | NA | 1 [Reference] | <.001 |
| >24 | 0.86 (0.8-0.93) | 0.82 (0.75-0.88) | ||
| Age, y | ||||
| <60 | 1 [Reference] | <.001 | 1 [Reference] | <.001 |
| ≥60 | 1.68 (1.55-1.82) | 1.3 (1.19-1.43) | ||
| Sex | ||||
| Male | 1 [Reference] | .07 | 1 [Reference] | .02 |
| Female | 0.93 (0.86-1.01) | 0.91 (0.85-0.99) | ||
| Race | ||||
| White | 1 [Reference] | .05 | 1 [Reference] | .61 |
| Black | 1.17 (1-1.37) | 1.07 (0.91-1.25) | ||
| Other | 0.88 (0.73-1.06) | 0.95 (0.78-1.15) | ||
| Comorbidity | ||||
| 0-1 | 1 [Reference] | <.001 | 1 [Reference] | <.001 |
| 2 | 1.76 (1.53-2.01) | 1.57 (1.37-1.81) | ||
| Disease site | ||||
| Oral tongue | 1 [Reference] | <.001 | 1 [Reference] | .002 |
| Floor of mouth | 1.31 (1.19-1.44) | 1.01 (0.91-1.12) | ||
| Gum | 1.31 (1.17-1.46) | 0.81 (0.71-0.91) | ||
| Palate | 1.49 (1.08-2.05) | 0.99 (0.88-1.11) | ||
| Other | 1.44 (1.29-1.59) | 0.87 (0.62-1.2) | ||
| Payer | ||||
| Private | 1 [Reference] | <.001 | 1 [Reference] | <.001 |
| Medicaid or Medicare | 1.9 (1.75-2.06) | 1.52 (1.38-1.66) | ||
| Not insured | 1.14 (0.93-1.4) | 1.02 (0.83-1.26) | ||
| Other | 1.54 (1.09-2.19) | 1.31 (0.92-1.87) | ||
| Pathologic T category | ||||
| 1 | 1 [Reference] | <.001 | 1 [Reference] | <.001 |
| 2 | 1.68 (1.52-1.86) | 1.54 (1.39-1.7) | ||
| 3 | 2.5 (2.15-2.91) | 2.12 (1.81-2.48) | ||
| 4 | 2.52 (2.29-2.77) | 2.25 (2.01-2.52) | ||
| Pathologic N category | ||||
| 0 | 1 [Reference] | <.001 | 1 [Reference] | <.001 |
| 1 | 1.62 (1.45-1.8) | 1.62 (1.45-1.8) | ||
| 2 | 2.82 (2.56-3.11) | 2.68 (2.41-2.99) | ||
| 3 | 8.75 (3.28-23.34) | 9.57 (3.51-26.05) | ||
| Depth of invasion, mm | ||||
| <40 | 1 [Reference] | 0.21 | 1 [Reference] | .64 |
| ≥40 | 1.02 (0.86-1.22) | 0.94 (0.79-1.12) | ||
| Unknown | 1.1 (0.98-1.24) | 0.95 (0.84-1.06) | ||
| Academic center | ||||
| No | 1 [Reference] | <.001 | 1 [Reference] | .12 |
| Yes | 0.92 (0.85-1.01) | 0.76 (0.58-0.99) | ||
| Unknown | 0.44 (0.34-0.57) | 0.97 (0.89-1.06) | ||
| Adjuvant chemotherapy | ||||
| None | 1 [Reference] | <.001 | 1 [Reference] | .11 |
| Yes | 1.62 (1.47-1.8) | 0.77 (0.6-0.99) | ||
| Unknown | 0.9 (0.7-1.16) | 1.03 (0.91-1.16) | ||
| Adjuvant radiation | ||||
| No or <5000 cGy | 1 [Reference] | <.001 | 1 [Reference] | <.001 |
| ≥5000 cGy | 1.31 (1.21-1.41) | 0.84 (0.77-0.92) | ||
| Margins | ||||
| Negative | 1 [Reference] | <.001 | 1 [Reference] | <.001 |
| Positive | 1.9 (1.71-2.11) | 1.5 (1.35-1.68) | ||
| Unknown | 1.88 (1.4-2.51) | 1.5 (1.12-2.02) | ||
| ECE in pN+a | ||||
| No | 1 [Reference] | <.001 | 1 [Reference] | NA |
| Yes | 1.59 (1.26-1.99) | |||
| Unknown | 1.19 (1.01-1.4) | |||
Abbreviations: ECE, extracapsular extension; NA, not applicable.
a
Number of resected nodes in quartiles and ECE (only in pN+) are not included in the multivariable model.