Table 1. Association of Baseline Demographic, Clinical, and Tumor Characteristics With Overall Survival.
| Characteristic | Siteman Cancer Center Registry | NCDB Patients, No. (%) | ||||
|---|---|---|---|---|---|---|
| Patients, No. (%) | Odds Ratio (95% CI) | |||||
| Frequency (n = 774) |
Alive at 5 Years (n = 699) |
Univariable (n = 774) |
Multivariable (n = 774)a |
Frequency (n = 104 788) |
Alive at 5 Years (n = 97 118) |
|
| Sex | ||||||
| Women | 562 (73) | 520 (93) | 1 [Reference] | 1 [Reference] | 80 871 (77) | 76 228 (94) |
| Men | 212 (27) | 179 (84) | 0.44 (0.27-0.71) | 0.64 (0.37-1.09) | 23 917 (23) | 20 890 (87) |
| Age, y | ||||||
| 18-39 | 198 (26) | 197 (99.5) | 1 [Reference] | 1 [Reference] | 26 760 (26) | 26 412 (99) |
| 40-49 | 165 (21) | 156 (95) | 0.09 (0.01-0.70) | 0.11 (0.01-0.92) | 25 370 (24) | 24 624 (97) |
| 50-59 | 189 (24) | 169 (89) | 0.04 (0.01-0.32) | 0.09 (0.01-0.67) | 24 552 (23) | 23 119 (94) |
| 60-69 | 131 (17) | 107 (82) | 0.02 (<0.01-0.17) | 0.05 (0.01-0.42) | 16 276 (16) | 14 370 (88) |
| >69 | 91 (12) | 70 (77) | 0.02 (<0.01-0.13) | 0.04 (0.01-0.32) | 11 830 (11) | 8593 (73) |
| Race | ||||||
| White or other | 684 (88) | 621 (91) | 1 [Reference] | NA | 95 124 (91) | 88 171 (93) |
| Black | 81 (11) | 69 (85) | 0.58 (0.30-1.14) | NA | 6769 (7) | 6169 (91) |
| Unknown | 9 (1) | NA | NA | NA | 2895 (2) | NA |
| Tobacco use | ||||||
| None | 416 (54) | 383 (92) | 1 [Reference] | NA | NA | NA |
| Current | 115 (15) | 95 (83) | 0.41 (0.23-0.75) | NA | NA | NA |
| Previous | 128 (17) | 112 (88) | 0.60 (0.32-1.14) | NA | NA | NA |
| Unknown | 115 (14) | NA | NA | NA | NA | NA |
| Alcohol use | ||||||
| None | 331 (43) | 300 (91) | 1 [Reference] | NA | NA | NA |
| Current | 282 (36) | 254 (90) | 0.94 (0.55-1.61) | NA | NA | NA |
| Previous | 28 (4) | 24 (86) | 0.62 (0.20-1.90) | NA | NA | NA |
| Unknown | 133 (17) | NA | NA | NA | NA | NA |
| Comorbidityb | ||||||
| None | 328 (42) | 321 (98) | 1 [Reference] | 1 [Reference] | 88 963 (84) | 83 869 (94) |
| Mild | 252 (33) | 232 (92) | 0.25 (0.11-0.61) | 0.41 (0.16-1.02) | 13 206 (13) | 11 438 (87) |
| Moderate/severe | 194 (25) | 146 (75) | 0.07 (0.03-0.15) | 0.12 (0.05-0.28) | 2619 (3) | 1811 (69) |
| Pathologic T stage | ||||||
| T1 or T2 | 549 (71) | 507 (92) | 1 [Reference] | 1 [Reference] | 66 464 (63) | 62 495 (94) |
| 17 241 (17) | 16 256 (94) | |||||
| T3 | 159 (21) | 139 (87) | 0.58 (0.33-1.01) | 0.55 (0.29-1.02) | 16 603 (16) | 15 022 (91) |
| T4 | 66 (9) | 53 (80) | 0.34 (0.17-0.67) | 0.34 (0.16-0.74) | 4480 (4) | 3345 (75) |
| AJCC TNM pathological stage | ||||||
| 1 | 519 (67) | 486 (94) | 1 [Reference] | NA | 64 602 (62) | 61 584 (95) |
| 2 | 61 (8) | 53 (87) | 0.45 (0.20-1.02) | NA | 7034 (7) | 6476 (92) |
| 3 | 131 (17) | 110 (84) | 0.36 (.20-0.64) | NA | 12 298 (12) | 10 958 (89) |
| 4 | 46 (6) | 36 (78) | 0.24 (0.11-0.54) | NA | 6096 (6) | 4531 (74) |
| Unknown | 17 (2) | NA | NA | NA | 14 758 (14) | NA |
Abbreviations: ACE-27, Adult Comorbidity Evaluation-27; AJCC, The American Joint Committee on Cancer; CCI, Charlson Comorbidity Index; NA, not applicable; NCDB, National Cancer Database; TNM, tumor, node, and metastasis.
a
Included variables on multivariable binary logistic regression were statistically significant on univariable binary logistic regression.
b
The instrument used to measure comorbidity in the Siteman cancer registry was ACE-27 index, and the instrument used to measure comorbidity in the NCDB was CCI.