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. 2017 Dec 18;29(2):410–419. doi: 10.1021/acs.bioconjchem.7b00726

Figure 5.

Figure 5

GRPR-specific imaging in PC-3 xenografted mouse model using 68Ga–NOTA–Aca–BBN7–14 and 68Ga–NOTA–PEG3–RM26. (A) Representative microcoronal PET scans of mice bearing PC-3 xenografts 15, 30, and 60 min after injection of 68Ga–NOTA–Aca–BBN7–14 and 68Ga–NOTA–PEG3–RM26. (B) PET quantification of tumor uptake in PC-3 tumors 15, 30, and 60 min after injection of 68Ga–NOTA–Aca–BBN7–14 (n = 4, mean ± SD) and 68Ga–NOTA–PEG3–RM26 (n = 3, mean ± SD), expressed as %ID/g_mean. (C) PET quantification of tumor uptake in PC-3 tumors 15, 30, and 60 min after the injection of 68Ga–NOTA–Aca–BBN7–14 (n = 4, mean ± SD) and 68Ga–NOTA–PEG3–RM26 (n = 3, mean ± SD), expressed as %ID/g_max.