Table 1.
Characteristics of the investigated studies of the association between the ALDH2 gene G487A (Glu504Lys) polymorphism and CAD in the Chinese population
| Author | Year | Region | Genotype | CAD | Control | Matching criteria | Sample size(CAD/control) | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| GG | GA | AA | GG | GA | AA | ||||||
| GuoYJ 7 | 2010 | Hunan | PCR‐RFLP | 219 | 171 | 27 | 291 | 135 | 22 | Age, gender, ethnicity, PHAC, HL | 417/448 |
| Wang YF 8 | 2014 | Liaoning | PCR‐LDR | 324 | 259 | 96 | 367 | 258 | 61 | Age, gender, ethnicity, BMI, TC, LDL‐C, BUN, Creatinine, Uric acid | 679/686 |
| Xu F 14 | 2011 | Beijing, Shandong | PCR | 291 | 227 | 28 | 372 | 165 | 9 | Age, gender,ethnicity, TG, smoking | 546/546 |
| BianY 15 | 2010 | Shandong | PCR | 54 | 48 | 4 | 146 | 63 | 3 | Age, gender, ethnicity, BMI, TG, TC, LDL‐C, smoking, PHAC | 106/212 |
| Cao L 16 | 2010 | Shandong | PCR | 92 | 53 | 24 | 93 | 47 | 11 | Age, gender, ethnicity, BMI, TG, TC, SBP, DBP | 169/151 |
| Jiang AH 17 | 2011 | Beijing | PCR | 106 | 48 | 8 | 25 | 8 | 1 | Gender, ethnicity | 162/34 |
| Tan Z 18 | 2013 | Hebei | PCR | 106 | 92 | 12 | 154 | 62 | 5 | Age, gender, ethnicity, BMI, PHAC TG, TC, HDL‐C, LDL‐C | 210/221 |
| Xia G 9 | 2011 | Shanghai | Taqman | 253 | 202 | 35 | 240 | 173 | 20 | Age, ethnicity, BMI, DB, HP, TG, TC, HDL‐C, LDL‐C | 490/433 |
| Zhao Q 19 | 2014 | Hunan | PCR | 57 | 44 | 7 | 19 | 6 | 1 | Age, gender, ethnicity | 108/26 |
CAD, coronary artery disease; HDL‐C, high‐density lipoprotein cholesterol; HP, hypertension; PCR‐LDR, Polymerase chain reaction‐ligase detection reaction; PCR‐RFLP, Polymerase chain reaction‐restriction fragment length polymorphism; Case–control study design was adopted in the above studies. PHAC, Positive history of alcohol consumption (%); HL, Hyperlipidaemia (%);TC, total cholesterol; TG, total triglycerides; SBP, systolic blood pressure; DBP, diastolic blood pressure; LDL‐C, low‐density lipoprotein cholesterol; HDL‐C, high‐density lipoprotein cholesterol; BMI, body mass index; DB, Diabetes; HP, hypertension.