Table 2.
Summary of meta‐analysis of association between ALDH2 gene G487A (Glu504Lys) polymorphism and CAD in the Chinese population
| Genetic model | Pooled OR (95% CI) | Z value | P value | Study number | CAD size | control size | P heterogeneity(I 2 %) |
|---|---|---|---|---|---|---|---|
| Allele genetic model | 1.830 (1.560–2.140) | 7.40 | 1.36 × 10−13 a | 9 | 2887 | 2757 | 0.02a (57.0) |
| Subgroup 1: GG0 < 160 | 2.170 (1.770–2.660) | 7.46 | 8.66 × 10−14 a | 5 | 755 | 644 | 0.56 (0) |
| Subgroup 2: GG0 > 160 | 1.670 (1.360–2.030) | 5.00 | 5.73 × 10−7 a | 4 | 2132 | 2113 | 0.01a (72.0) |
| Recessive genetic model | 1.920 (1.530–2.390) | 5.70 | 1.20 × 10−8 a | 9 | 2887 | 2757 | 0.79 (0) |
| Dominant genetic model | 1.593 (1.336–1.900) | 5.18 | 2.22 × 10−7 a | 9 | 2887 | 2757 | 0.027a (53.7) |
| Subgroup 1: GG1 < 150 | 1.875 (1.485–2.367) | 5.28 | 1.29 × 10−7 a | 5 | 755 | 644 | 0.42 (0) |
| Subgroup 2: GG1 > 150 | 1.460 (1.171–1.821) | 3.36 | 7.79 × 10−4 a | 4 | 2132 | 2113 | 0.022a (68.9) |
| Homozygous genetic model | 2.280 (1.810–2.870) | 6.97 | 3.17 × 10−12 a | 9 | 2887 | 2757 | 0.66 (0) |
| Heterozygous genetic model | 3.330 (2.070–5.370) | 4.94 | 7.81 × 10−7 a | 9 | 2887 | 2757 | <0.00001a (86.0) |
| Subgroup 1: GA1 < 100 | 4.370 (1.650–11.530) | 2.98 | 0.003a | 5 | 755 | 644 | <0.00001a (86.0) |
| Subgroup 2: GA1 > 100 | 2.630 (1.510–4.590) | 3.40 | 0.0007a | 4 | 2132 | 2113 | <0.00001a (89.0) |
a
P ≤ 0.05.
CAD, coronary artery disease; CI, confidence interval; OR, odds ratio; CAD size, the total number of CAD cases; control size, the total number of control group; Allele genetic model, total A allele versus total G allele; recessive genetic model, AA versus GG+GA; Dominant genetic model: AA+GA versus GG; Homozygous genetic mode, AA versus GG; Heterozygous genetic model, GA versus GG.