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. 2017 Dec 20;22(3):1614–1626. doi: 10.1111/jcmm.13436

Figure 6.

Figure 6

The down‐regulation of ATF4 increases cells sensitivity to ATO. (A) ATF4 was detected by Western blot in SUP‐B15 and TOM‐1 cells after a 24‐hr treatment with ATO and/or Dasatinib. (B) SUP‐B15 cells were stably transfected with shNC, shATF4‐1 and shATF4‐2. (C) Apoptosis was measured in the stably transfected cells with or without ATO (2 μΜ) treatment for 24 hrs. (D) caspase‐9, 3 and PARP were detected by Western blot in the stably transfected cells after ATO (2 μΜ) treatment for 24 hrs. Bars represent the mean ± S.E.M, n = 3. ***P < 0.001 versus shNC ATO group.