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. 2017 Dec 20;22(3):1507–1516. doi: 10.1111/jcmm.13416

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© 2017 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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S1P analogue (FTY720‐P)‐induced contractility of rat corpus cavernosum smooth muscle (CCSM) in vitro. Panel A, B and C are FTY720‐P‐induced dose–response force tracings of rats CCSM from sham (A), castration (B) and castration + T (C) groups, respectively. For typical tracings, the x‐axis represents time (min.), while the y‐axis represents force (mg). Panel D is a summary graph for the data shown in panel A–C. Maximal response to KCl was taken as 100%, while the contractility of FTY720‐P was evaluated as a percentage of this response. Values are expressed as means ± S.E. **P < 0.01 versus sham or castration + T. (n = CC strips obtained from 7 to 8 different rats for each group).