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. 2017 Nov 23;22(3):1769–1777. doi: 10.1111/jcmm.13458

Figure 5.

Figure 5

Differential activation of S1PRs mediated the S1P‐induced sICAM‐1 up‐regulation of GEnCs in the presence of MPO‐ANCA‐positive IgG. A. S1PR1 antagonist W146 significantly increased sICAM‐1 level in the supernatants of GEnC stimulated by S1P plus MPO‐ANCA‐positive IgG. B. S1PR1 agonist SEW significantly reduced sICAM‐1 level in the supernatants of GEnC stimulated by S1P plus MPO‐ANCA‐positive IgG. C. S1PR2 antagonist JTE significantly reduced sICAM‐1 level in the supernatants of GEnC stimulated by S1P plus MPO‐ANCA‐positive IgG. D. S1PR3 antagonist TY significantly reduced sICAM‐1 level in the supernatants of GEnC stimulated by S1P plus MPO‐ANCA‐positive IgG. E. S1PR4 antagonist CYM significantly reduced sICAM‐1 level in the supernatants of GEnC stimulated by S1P plus MPO‐ANCA‐positive IgG. F. S1PR5 agonist A97 significantly increased sICAM‐1 level in the supernatants of GEnC stimulated by S1P plus MPO‐ANCA‐positive IgG. Bars represent mean ± S.D. of repeated measurements of five independent experiments or donors.