• Introduction

• High‐cholesterol levels increase chemokine signalling

• Role of different monocyte subsets in atherosclerosis

• NR4A1‐deficient animal model

• Factors that associate impaired fat metabolism with the inflammatory responses in atherosclerosis

‐ Liver X receptors

‐ High cholesterol and hematopoietic progenitor cells

• The repertoire of hematopoietic progenitor cells is biased towards the preferential myeloid production in atherogenesis

• Mechanisms of monocyte release from the bone marrow

• Local macrophage proliferation is a major source of lesional macrophages

• Contribution of monocytes to plaque progression

• Factors that regulate macrophage retention or emigration from the plaque

• Neutrophils and their role in atherosclerosis

‐ Function and characteristics of neutrophils

‐ Components of neutrophil granules

‐ Neutrophilia and hypercholesterolaemia

‐ Mediators of neutrophil recruitment to lesions

‐Neutrophil granule components in atherosclerosis

‐ NETs in atherosclerosis

• Conclusion

• Acknowledgement

• Conflict of interest